Between 1980 and 1988,126 patients with leukemia were treated with piperazinedione and fractionated total body irradiation (TBI) followed by allogeneic bone marrow transplantation from HLA matched siblings. Sixty-one patients had acute myelogenous leukemia, 46 acute lymphoblastic leukemia, and 19 ch
Allogeneic bone marrow transplantation for hematological malignancies following etoposide, cyclophosphamide, and fractionated total body irradiation
โ Scribed by Dr. Jonathan C. Yau; Susan D. Huan; Charles F. Lemaistre; Carole M. Meneghetti; Borje S. Andersson; Ralph O. Wallerstein; Shiao Y. Woo; Lane J. Brunner; Meletios A. Dimopoulos; Sundar Jagannath; Albert B. Deisseroth; Gary Spitzer; Verneeda Spencer; Jorge A. Spinolo; Karel A. Dicke; Sergio Giralt
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 474 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0361-8609
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## Abstract To circumvent the cardiac toxicity of highโdose cyclophosphamide (CY) in the myeloablative conditioning for those with cardiac comorbidity, we developed a new cardiac sparing conditioning regimen (VP/rCY/TBI) composed of 12 Gy of total body irradiation (TBI), etoposide (VPโ16) (40 mg/kg