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Allocolchicines via Intramolecular Nicholas Reactions: The Synthesis of NSC 51046

✍ Scribed by Djurdjevic, Sinisa; Green, James R.


Book ID
126934356
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
90 KB
Volume
9
Category
Article
ISSN
1523-7060

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Synthesis of 11-Membered Enediyne Ketone
✍ Maier, Martin E. ;Brandstetter, Tilmann πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 939 KB

## Abstract An efficient route to 11‐membered enediyne ketones 13 and 22 was developed. This route is based on an intramolecular Nicholas reaction of 11 and 20, respectively. In the course of the preparation of the cyclization substrates 11 and 20, it was important to use the acetylenic alcohols 6