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Allergic reaction to local anesthetic agents of the amide group

Book ID
119496552
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
116 KB
Volume
100
Category
Article
ISSN
1097-6825

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Thiazolyl-N-substituted amides: A group
Thiazolyl-N-substituted amides: A group of effective anti-inflammatory agents with potential for local anesthetic properties. Synthesis, biological evaluation, and a QSAR approach
✍ Dimitra Hadjipavlou-Litina; Athina Geronikaki; Remi Mgonzo; Irini Doytchinova πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 177 KB πŸ‘ 1 views

A series of thiazolyl-N-substituted amides were synthesized and tested for anti-inflammatory activity. Their R M values were determined as an expression of their lipophilicity. Theoretical calculation of their lipophilicity, as clog P and log D 7.4 was also performed. The effect of the synthesized c