Allergenic properties of naturally occurring cannabinoids

✍ Scribed by Edna S. Watson; James C. Murphy; Carlton E. Turner

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 242 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720831

✦ Synopsis

The guinea pig maximization test was used to determine the potential of seven cannabinoids to produce allergic contact dermatitis. A9-Tetrahydrocannabinol and cannahinol were found to be extreme (Grade V) sensitizers. Cannabidiol, A8-tetrahydrocannabinol, and cannabichromene were moderate (Grade 111) sensitizers. Cannabigerol and cannabinol methyl ether were not sensitizers. Most of the cannabinoids were found to be allergenically cross-reactive. Additionally, it was shown that the presence of a free 1'-hydroxyl group was required for sensitization, but not to elicit a response in sensitive animals.

Keyphrases 0 Cannabinoids-naturally occurring, allergenic properties, determined by the guinea pig maximization test for skin sensitivity 0 Allergenicity-of naturally occurring cannabinoids, guinea pig maximization test for skin sensitivity Sensitizers, skin-allergenic properties of naturally occurring cannabinoids, guinea pig maximization test