Allenic amides by hydration of allenic nitriles with alkaline hydrogen peroxide and by a hitter reaction.

✍ Scribed by P.M. Greaves; Phyllis D. Landor; S.R. Landor; O. Odyek

• Book ID: 104246616
• Publisher: Elsevier Science
• Year: 1973
• Tongue: French
• Weight: 99 KB
• Volume: 14
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)95621-7

✦ Synopsis

We have recently described general methods for the synthesis of allenic nitrilcsl which rendered these compounds readily available. Some of these nitriles were intended as starting materials for the synthesis of allenic acids, acid chlorides, esters and amides in connection with our progranrme ou biologically active allenes.

However, strong nucleophiles preferably attack allenic nitriles in the Michael position (cf formation of enamine nitriles from the reaction with amines2) and the