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Allelotyping Nephrogenic Rests: Putative Precursor Lesions of Wilms Tumors

โœ Scribed by Anirban Maitra; Syed Salahuddin; Charles F. Timmons; Adi F. Gazdar

Book ID
106249844
Publisher
Springer
Year
1999
Tongue
English
Weight
481 KB
Volume
2
Category
Article
ISSN
1093-5266

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Nephrogenic rests (NR) are abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney. Though NR are best known as precursors of Wilms tumor (WT), many alternative fates are observed, and most rests are destined for eventual atresi

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We report a case of synchronous bilateral Wilms' tumor in a girl with incomplete Beck-with-Wiedemann syndrome and hemihypertrophy. Multiple small tumors were present in both kidneys. The initial diagnostic biopsy showed stage I monophasic blastematous Wilms' tumor of favorable histology, with multip

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## BACKGROUND. Studies regarding different ethnic populations of children with Wilms' tumor (WT) in the U. S. have shown differences between age and gender incidence and the type of its precursor lesions (nephrogenic rests). To the authors' knowledge there are few reports in the literature regardi