Allelic variations of RANK/RANKL/OPG signaling system is related to bone mineral density and in vivo gene expression

Genetic variation in the RANKL/RANK/OPG

Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men

✍ Delnaz Roshandel; Kate L Holliday; Stephen R Pye; Steven Boonen; Herman Borghs; 📂 Article 📅 2010 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 220 KB 👁 1 views

## Abstract The aim of this study was to determine if single‐nucleotide polymorphisms (SNPs) in __RANKL__, __RANK__, and __OPG__ influence bone turnover and bone mineral density (BMD) in men. Pairwise tag SNPs (__r__^2^ ≥ 0.8) were selected for __RANKL__, __RANK__, and __OPG__ and their 10‐kb flank