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Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression

✍ Scribed by Straub, R E; Lipska, B K; Egan, M F; Goldberg, T E; Callicott, J H; Mayhew, M B; Vakkalanka, R K; Kolachana, B S; Kleinman, J E; Weinberger, D R


Book ID
110060262
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
220 KB
Volume
12
Category
Article
ISSN
1359-4184

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The levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD65 and GAD67, were measured in subpopulations of striatal neurons in adult rats depleted of dopamine as neonates with 6-OHDA and chronically injected with vehicle or with the dopamine receptor agonists apomorphine or SK