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Allelic losses on chromosome band 11q13 in aldosterone-producing adrenal tumors

✍ Scribed by Aritoshi Iida; Yusuke Nakamura; Takashi Imai; Kirsten Blake; Terry Tunny; Shelley Klemm; Michael Stowasser; Richard Gordon; Nicholas Hayward

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 516 KB
Volume: 12
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870120114

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✦ Synopsis

We examined loss of heterozygosity (LOH) in I 4 aldosterone-producing adrenal tumors, with six linearly ordered restriction fragment length polymorphism (RFLP) markers that map within a 12-cM region containing the MEN/ locus on I I q 13. Among I I tumors that were informative for at least one marker, five showed LOH at one or more loci, and two distinct regions of deletion were identified. The proximal region overlapped with the location of the MEN/ locus previously predicted by linkage analyses in MENl families and the commonly deleted region in hyperparathyroid tumors. This suggests that one of the genes associated with development of aldosterone-producing adrenal tumors may coincide with the MEN/ locus, and that a second Rene, distal to the MEN/ locus, may also play a role in the development of this type of tumor. Genes Chrornosorn Cancer -. I

12:73-75 (199.5).

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