Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers

Allelic loss at BRCA1, BRCA2, and adjace

Allelic loss at BRCA1, BRCA2, and adjacent loci in relation to TP53 abnormality in breast cancer

✍ Su-Ling Tseng; Jyh-Cherng Yu; Chung-Tai Yue; Shu-Fen Chang; Tzu-Ming Chang; Chen 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 60 KB 👁 2 views

Cells with abnormal TP53 lose cell cycle checkpoints, resulting in genomic instability and neoplastic transformation. However, the evidence linking the tumor-specific targets of genomic alteration to an abnormal TP53 is limited. The present study tested the hypothesis that TP53 abnormalities are cor