Allelic loss at the 8p22 region as a prognostic factor in large and estrogen receptor negative breast carcinomas
✍ Scribed by Yoshihito Utada; Shunsuke Haga; Tetsuro Kajiwara; Fujio Kasumi; Goi Sakamoto; Yusuke Nakamura; Mitsuru Emi
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 95 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND. Allelic losses of tumor suppressor genes, or the chromosomal regions harboring them, in the DNA of tumor cells may become useful postoperative prognostic indicators. The authors studied frequent loss of heterozygosity (LOH) on chromosome 8p22 and its association with disease progression that occurred later in patients with breast carcinoma.
METHODS.
To examine whether allelic losses at 8p22 might correlate with postoperative survival during a 5-year period of prospective follow-up, the authors tested tumors from a cohort of 298 breast carcinoma patients informative for 8p22 markers. The tumors were tested for allelic losses of microsatellite markers D8S136 and D8S1106 located at 8p22, a chromosomal region where genetic alterations are frequent in breast carcinomas.