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Allelic loss at 1 p is associated with tumor progression of meningiomas

✍ Scribed by M. Josefa Bello; Angel Pestaña; Juan A. Rey; Jose M. De Campos; M. Elena Kusak; Jesus Vaquero; Jose L. Sarasay

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
313 KB
Volume
9
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Next to chromosome 22 anomalies, deletions of the short arm of chromosome I have previously been described as the most frequent alteration detected by cytogenetic analysis of meningiomas. To determine the incidence of these deletions, we have analyzed a series of 50 meningiomas for the loss of alleles at four chromosome I loci. Thirteen samples displayed LOH for the markers studied; in one instance, the results were compatible with loss of the entire chromosome I, whereas in the other 12 samples deletions of the short arm were observed. Eleven of the meningiomas had previously been shown to have loss of alleles on chromosome 22, and 12 of them were characterized by increased tumor aggressiveness. These findings suggest that deletion of 1p (or the alteration of a locus located there) might represent a secondary, but nonrandom alteration in meningiomas, perhaps contributing to meningioma tumor progression. Genes Chrom Cancer 9:296‐298 (1994). © 1994 Wiley‐Liss. Inc.

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