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Allelic Inclusion in a Pre-B-Cell Line that Generates Immunoglobulin Heavy Chain Genes in vitro

✍ Scribed by Gabriele Beck-Engeser, Hans-Martin Jäck and Matthias Wabl

Book ID
123633733
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
920 KB
Volume
84
Category
Article
ISSN
0027-8424

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## A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro The functional immunoglobulin (Ig) genes of B lymphocytes undergo somatic mutations during immune responses. These mutations modify the antigen binding site of the immunoglobulins, thereby enhancin