✦ LIBER ✦

Allelic imbalance on chromosome I in human breast cancer. I. Minisatellite and rflp analysis

✍ Scribed by Marie-Louise Loupart; Susan Adams; William Brammar; John Armour; Rosemary Walker; Jennifer Varley

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 901 KB
Volume: 12
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870120104

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Allelic imbalance on chromosome I in hum

Allelic imbalance on chromosome I in human breast cancer. II. Microsatellite repeat analysis

✍ Nigel Hoggard; Bill Brintnell; Jennifer Varley; Anthony Howell; Jean Weissenbach 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 720 KB

## Abstract We have determined regions of allelic imbalance in human breast cancer cells using highly polymorphic microsatellite markers, which can be rapidly typed by the polymerase chain reaction (PCR) using very small amounts of DNA. It appears that there are several regions of chromosome I whic

Fractional allelic imbalance in human br

Fractional allelic imbalance in human breast cancer increases with tetraploidization and chromosome loss

✍ Cees J. Cornelisse; Nel Kuipers-Dijkshoorn; Margreethe van Vliet; Jo Hermans; Pe 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 606 KB

We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (Al, allelic loss or allelic gain) in the tumor. Here we report the statist

At least two different regions are invol

At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer

✍ Dr. Anne-Marie Cleton-Jansen; Elna W. Moerland; Net J. Kuipers-Dijkshoorn; Cees 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 565 KB

## Abstract Loss of heterozygosity (LOH) or allelic imbalance, the latter term referring to both loss and gain of an allele, on the long arm of chromosome 16 has been repeatedly found in cancers of, e.g., the breast and prostate. This indicates the presence of one or more tumor suppressor genes on

Allelic imbalance study of 16q in human

Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers

✍ F. Dorion-Bonnet; S. Mautalen; I. Hostein; M. Longy 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 930 KB

## Abstract The high incidence of allelic imbalance on the long arm of chromosome 16 in breast cancer suggests its involvement in the development and progression of the tumor. Several loss of heterozygosity (LOH) studies have led to the assignment of commonly deleted regions on 16q where tumor supp

Chromosome I alterations in breast cance

Chromosome I alterations in breast cancer: Allelic loss on Ip and Iq Is related to lymphogenic metastases and poor prognosis

✍ Åke Borg; Qiu-Xia Zhang; Håkan Olsson; Eva Wenngren 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 960 KB

The development of human breast cancer is characterized by a variety of genetic alterations, and cytogenetic analyses have documented the consistent involvement of both arms of chromosome I. In the present study, molecular markers detecting restriction fragment length polymorphisms were used in pair

High frequency of allelic imbalance at c

High frequency of allelic imbalance at chromosome region 16q22-23 in human breast cancer: Correlation with high pgr and low s phase

✍ Sigurlaug Skirnisdottir; Gudny Eiriksdottir; Trausti Baldursson; Rosa B. Barkard 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 668 KB

The loss of genetic material from a specific chromosome region in tumors suggests the presence of tumor-suppressor genes. Loss of heterozygosity (LOH) or allelic imbalance (Al) on the long arm of chromosome 16 is a known event in sporadic breast cancer. To locate the commonly deleted regions, and th