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Allelic frequency of the MCP-1 promoter −2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis

✍ Scribed by A. Ruhi Özyürek; Dolunay Gürses; Zülal Ülger; Ertürk Levent; A. Rahmi Bakiler; Afig Berdeli


Publisher
Springer
Year
2006
Tongue
English
Weight
107 KB
Volume
26
Category
Article
ISSN
0770-3198

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## Abstract 6‐Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are the major determinants of interindividual differences in the severe toxicity or efficacy of 6MP. Four varia