Allelic changes at multiple regions of chromosome 5 are associated with progression of urinary bladder cancer
✍ Scribed by von Knobloch, Rolf; Bugert, Peter; Jauch, Anna; K�lble, Tilman; Kovacs, Gyula
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 226 KB
- Volume
- 190
- Category
- Article
- ISSN
- 0022-3417
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✦ Synopsis
This study has analysed 65 urothelial carcinomas for allelic imbalance at 22 loci of chromosome 5 and has determined three regions of interest. A commonly duplicated region was mapped to chromosome 5p between loci D5S1473 and D5S819, one region of deletion to chromosome 5q22±23 between loci D5S2055 and D5S659, and another to chromosome 5q33±34 between loci D5S1456 and D5S1465. An allelic imbalance was detected in 54% of the cases. Only 10% of grade 1 tumours showed allelic changes at chromosome 5, whereas 60% and 63% of grade 2 and grade 3 cancers, respectively, had alterations of chromosome 5. The frequency of chromosome 5 changes increased from 24% in pTa tumours up to 72% in pT3±4 tumours. Of particular interest, ten out of 12 urothelial carcinomas showing metastatic growth in regional lymph nodes at the time of cystectomy had alterations at chromosome 5. No speci®c region, but genetic changes in general were associated with the grading and staging of bladder cancers.