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Allelic and haplotypic association ofGABRA2 with alcohol dependence

โœ Scribed by Covault, Jonathan ;Gelernter, Joel ;Hesselbrock, Victor ;Nellissery, Maggie ;Kranzler, Henry R.

Book ID
101451512
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
136 KB
Volume
129B
Category
Article
ISSN
0148-7299

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Genetic association studies have implicated the TaqI A1 allele of the human dopamine D2 receptor gene (DRD2) as a riskdetermining factor for alcohol dependency. However, as alcoholism is a disease of polygenic inheritance, the percentage of overall disease variance explained by the TaqI A1 allele is