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Allele-Specific p53 Mutant Reactivation

✍ Scribed by Xin Yu; Alexei Vazquez; Arnold J. Levine; Darren R. Carpizo


Book ID
113524112
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
781 KB
Volume
21
Category
Article
ISSN
1535-6108

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## Abstract Mutant forms of the p53 gene have been shown to cooperate with an activated ras gene in transforming primary cells in culture. The aberrant proteins encoded by p53 mutants are thought to act in a dominant negative manner in these assays. In vivo data, however, reveal that where p53 has