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Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

โœ Scribed by LaFramboise, Thomas; Weir, Barbara A.; Zhao, Xiaojun; Beroukhim, Rameen; Li, Cheng; Harrington, David; Sellers, William R.; Meyerson, Matthew


Book ID
120208245
Publisher
Public Library of Science
Year
2005
Tongue
English
Weight
478 KB
Volume
1
Category
Article
ISSN
1553-734X

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The insulin-like growth factor II (IGF2) gene is imprinted with the paternal allele expressed and the maternal one silent. Loss of imprinting (LOI) of IGF2 has been suggested to play a role in the development of tumours, but the reported incidence of IGF2 LOI in tumours shows considerable variation,