The choice of allele-sharing statistics can have a great impact on the power of robust affected relative methods. Similarly, when allele-sharing statistics from several pedigrees are combined, the weight applied to each pedigree's statistic can affect power. Here we describe the direct connection be
β¦ LIBER β¦
Allele-Sharing Statistics Using Information on Family History
β Scribed by A. Callegaro; I. Meulenbelt; M. Kloppenburg; P. E. Slagboom; J. J. Houwing-Duistermaat
- Book ID
- 111111576
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 186 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0003-4800
No coin nor oath required. For personal study only.
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## Abstract The haplotypeβsharing correlation (HSC) method for association analysis using family data is revisited by introducing a permutation procedure for estimating regionβwise significance at each marker on a study segment. In simulation studies, the HSC method has a correct type 1 error rate