✦ LIBER ✦

Allele-Sharing Models: LOD Scores and Accurate Linkage Tests

✍ Scribed by Augustine Kong; Nancy J. Cox

Book ID: 117852198
Publisher: American Society of Human Genetics
Year: 1997
Tongue: English
Weight: 143 KB
Volume: 61
Category: Article
ISSN: 0002-9297
DOI: 10.1086/301592

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Incorporating endophenotypes into allele

Incorporating endophenotypes into allele-sharing based linkage tests

✍ Wen-Chang Wang; I-Shou Chang; Chin-Hao Chang; David Curb; Low-Tone Ho; Chao A. H 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

## Abstract For a genetic study in which there are concordant and discordant sibpairs for a complex disease trait and the measurements of other endophenotypes/intermediate phenotypes for each of the individuals are also available, we describe an allele‐sharing based multipoint linkage test that uti

Estimation and test for linkage between

Estimation and test for linkage between markers: a comparison of lod score andχ2test in a linkage study of maritime pine (Pinus pinasterAit.)

✍ S. Gerber; F. Rodolphe 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 409 KB

The first step in the construction of a linkage map involves the estimation and test for linkage between all possible pairs of markers. The lod score method is used in many linkage studies for the latter purpose. In contrast with classical statistical tests, this method does not rely on the choice o

The Quantitative LOD Score: Test Statist

The Quantitative LOD Score: Test Statistic and Sample Size for Exclusion and Linkage of Quantitative Traits in Human Sibships

✍ Grier P. Page; Christopher I. Amos; Eric Boerwinkle 📂 Article 📅 1998 🏛 American Society of Human Genetics 🌐 English ⚖ 118 KB

Linkage of familial alzheimer disease to

Linkage of familial alzheimer disease to chromosome 14 in two large early-onset pedigrees: Effects of marker allele frequencies on lod scores

✍ Nechiporuk, A. ;Fain, P. ;Kort, E. ;Nee, L. E. ;Frommelt, E. ;Polinsky, R. J. ;K 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB 👁 2 views

Alzheimer disease (AD) is a devastating neurodegenerative disease leading to global dementia. In addition to sporadic forms of AD, familial forms (FAD) have been recognized. Mutations in the amyloid precursor protein (APP) gene on chromosome (CHR) 21 have been shown to cause early-onset AD in a smal