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A two-color BCR–ABL probe that greatly r

A two-color BCR–ABL probe that greatly reduces the false positive and false negative rates for fluorescence in situ hybridization in chronic myeloid leukemia

✍ F. H. Grand; A. Chase; S. Iqbal; D. X. Nguyen; J. L. Lewis; S. B. Marley; R. J. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 274 KB 👁 1 views

The t(9;22) translocation resulting in the fusion of BCR and ABL genes is pathognomonic in chronic myeloid leukemia (CML) and may be investigated at the molecular level using fluorescence in situ hybridization (FISH). Two-color BCR-ABL probes visualizing one fusion signal (1F FISH) have high false p