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All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells

✍ Scribed by Marumi Ohno; Yoshinori Ikenaka; Mayumi Ishizuka


Book ID
116302719
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
411 KB
Volume
417
Category
Article
ISSN
0006-291X

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Background and Objectives: Retinoids are metabolized in human intestinal epithelial cells to all-trans retinoic acid; however, it is unknown whether these cells express retinoid receptors, and whether sensitivity or resistance to the hormone is associated with a particular pattern of expression of r