All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells
β Scribed by Kawin Leelawat; Kenoki Ohuchida; Kazuhiro Mizumoto; Chulabhorn Mahidol; Masao Tanaka
- Book ID
- 116333413
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 264 KB
- Volume
- 224
- Category
- Article
- ISSN
- 0304-3835
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## Abstract Allβtrans retinoic acid (ATRA), a synthetic derivative of vitamin A, inhibits the growth of breast cancer cells. To elucidate the mechanism by which ATRA causes cell growth inhibition, we examined changes in cell cycle and intracellular signaling pathways, focusing on protein kinase C (