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All-trans retinoic acid inhibits proliferation of intestinal epithelial cells by inhibiting expression of the gene encoding Krüppel-like factor 5

✍ Scribed by Sengthong Chanchevalap; Mandayam O. Nandan; Didier Merlin; Vincent W. Yang


Book ID
116465044
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
307 KB
Volume
578
Category
Article
ISSN
0014-5793

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## Abstract The present study examined the effects of all‐__trans__ retinoic acid (tRA) on proliferation and expression of the IGF system in Caco‐2 human colon adenocarcinoma cells. tRA inhibited Caco‐2 cell proliferation in a dose‐dependent manner, with a 40 ± 2% decrease in cell number observed 4