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All-Trans-Retinoic Acid Induces Interleukin-8 via the Nuclear Factor-kappaB and p38 Mitogen-Activated Protein Kinase Pathways in Normal Human Keratinocytes

โœ Scribed by Dai, Xiuju; Yamasaki, Kenshi; Shirakata, Yuji; Sayama, Koji; Hashimoto, Koji


Book ID
110733343
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
318 KB
Volume
123
Category
Article
ISSN
0022-202X

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi