All-trans retinoic acid downregulates ALK in neuroblastoma cell lines and induces apoptosis in neuroblastoma cell lines with activated ALK
β Scribed by Hitoyasu Futami; Ryuichi Sakai
- Book ID
- 116335497
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 598 KB
- Volume
- 297
- Category
- Article
- ISSN
- 0304-3835
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Oral squamous cell carcinoma (OSCC) may arise from potentially malignant oral lesions. Allβ__trans__ retinoic acid (atRA), which plays a role in cell growth and differentiation, has been studied as a possible chemotherapeutic agent in the prevention of this progression. While the mechan
The human neuroblastoma cell line SK-N-BE, after incubation with 10 mM retinoic acid (RA) or 20 nM phorbol 12-myristate 13-acetate (PMA), underwent biochemical and morphological signs of differentiation within 10-14 days. In parallel, SK-N-BE cells produced significantly higher amounts of nitric oxi