✦ LIBER ✦

All roads lead to Rome? The multiple pathways of protein folding

✍ Scribed by Jonathan S. Weissman

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 762 KB
Volume: 2
Category: Article
ISSN: 1074-5521
DOI: 10.1016/1074-5521(95)90044-6

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✦ Synopsis

All roads lead to Rome? The multiple pathways of protein folding

Recent studies have found that protein folding reactions often proceed through two or more kinetically distinct pathways. In at least some cases, the observed folding intermediates act as kinetic traps, slowing the rate at which folding is completed. These findings have important implications for understanding how proteins fold in vitro and in vivo.

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