ALL- and CML-type BCR/ABL mRNA transcripts in chronic myelogenous leukemia and related disorders
β Scribed by Akihiko Yokohama; Masamitsu Karasawa; Kiyoshi Okamoto; Hirotaka Sakai; Takuji Naruse
- Book ID
- 114119612
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 318 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0145-2126
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The Philadelphia chromosome is present in more than 95% of chronic myelogenous leukemia patients and in up to 25% of patients with acute lymphocytic leukemia. The major consequence of the aberration is the fusion of the ABL and BCR genes. The position of the breakpoint on chromosome 22 determines wh
## Abstract During the formation of the Philadelphia (Ph) chromosome, in the majority of chronic myelogenous leukemia (CML) patients, the chromosome 22 breakpoint is located in the major breakpoint cluster region of the BCR gene (Mβbcr). Minor and micro breakpoint cluster regions (mβbcr with e1a2 t