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Alkynylation of carbonyl compounds with terminal acetylenes promoted by ZnCl2 and Et3N: simple, mild and efficient preparation of propargylic alcohols

โœ Scribed by Biao Jiang; Yu-Gui Si

Book ID
104252206
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
121 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A mild and efficient addition of terminal acetylenes to carbonyl compounds in the presence of ZnCl 2 and Et 3 N gives propargylic alcohols in good to high yields.

๐Ÿ“œ SIMILAR VOLUMES

InBr3โ€“Et3N promoted alkynylation of alde
InBr3โ€“Et3N promoted alkynylation of aldehydes and N,O-acetals under mild conditions: facile and simple preparation of propargylic alcohols and amines
โœ Norio Sakai; Maki Hirasawa; Takeo Konakahara ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 80 KB

The use of a novel InBr 3 -Et 3 N reagent system to promote addition reactions of 1-alkynes not only with a variety of aromatic or bulky aliphatic aldehydes but also with N,O-acetals is described. The corresponding propargylic alcohols or amines are produced in good to excellent yields.