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Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

✍ Scribed by Ute Haedke; Markus Götz; Philipp Baer; Steven H.L. Verhelst

Book ID
113495344
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
636 KB
Volume
20
Category
Article
ISSN
0968-0896

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Mechanism-based isocoumarin inhibitors f
Mechanism-based isocoumarin inhibitors for serine proteases: Use of active site structure and substrate specificity in inhibitor design
✍ James C. Powers; Chih-Min Kam; Lakshmi Narasimhan; Joszef Oleksyszyn; Maria A. H 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 781 KB

Isocoumarins are potent mechanism-based heterocyclic irreversible inhibitors for a variety of serine proteases. Most serine proteases are inhibited by the general serine protease inhibitor 3,4-dichloroisocoumarin, whereas isocoumarins containing hydrophobic 7-acylamino groups are potent inhibitors f