Reductive N-alkylation of amides, carbam
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Daniel Dubé; Andrew A. Scholte
📂
Article
📅
1999
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Elsevier Science
🌐
French
⚖ 171 KB
A one pot selective mend N-alkylation of primary amides, thioamides, carbamates and ureas has been developed using aromatic and aliphatic aldehydes as alkylating agents and trifluoroacetic acid / triethylsilane as reagents. Application to an efficient synthesis of a primary amine from the correspond