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Alkylation of methyl acetoacetate and gas chromatographic analysis of products. An organic laboratory experiment

โœ Scribed by Schimelpfenig, C. W.


Book ID
124081234
Publisher
American Chemical Society
Year
1977
Tongue
English
Weight
502 KB
Volume
54
Category
Article
ISSN
0021-9584

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Gas chromatographic and mass spectrometr
โœ K. K. Midha; D. V. C. Awang; I. J. McGilveray; J. Kleber ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 657 KB

Gas chromatographic analysis of the products of reaction of diazomethane with tolbutamide and chlorpropamide indicates the formation of three compounds in both cases. As expected, N-methylation (at sulfonamide nitrogen) is the predominant reaction; minor amounts of O-methylated product are also obse