Alkylation of carbonyl compounds with dialkylzirconocene complexes promoted by potassium t-butoxide

✍ Scribed by Ann L. Larson; Diana L. Baker; Robert W. Towne; Daniel A. Straus

• Publisher: Elsevier Science
• Year: 1991
• Tongue: French
• Weight: 172 KB
• Volume: 32
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)79419-6

✦ Synopsis

Potassrum r-butoxlde promotes alkylation of non-enohzable ketones and aldehydes by zlrconocene dmlkyls The reaction proceeds wdh loss of cyclopentachemde Ion from the metal center Organozlrcomum complexes are finding Increasing use In orgamc synthesis 1 The maJorlty of developments m this area mvolve bls($-cyclopentadlenyl)wrcomum ("zlrconocene") denvatlves Whereas complexes of the type RZr(OR')j have long been known to react as nucleophlles toward carbonyl substrates,* zlrconocene alkyls do not, transmetalafion has ken used previously to overcome this hnutatlon 3 We report here that addmon of 4-5 eq of KOt-Bu to a THF solution of Cp2ZrR2