Alkylation of an imidazolidine enaminoester: A new sequence for the Cα-alkylation of 4,5-dihydroimidazoles

✍ Scribed by Raymond C.F Jones; Pravin Patel; Simon C Hirst; Ian Turner

• Book ID: 104207996
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 608 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(97)00752-7

✦ Synopsis

l-Benzyl-2-(ethoxycarbonylmethylene)-2,3,4,5-tetrahydroimidazole undergoes preferred Calkylation with halogenoalkanes, dihalogenoalkanes and epoxides; subsequent removal of of the ethoxycarbonyl group provides a new route to 2-alkyl-4,5-dihydroimidazoles. 1.3-Dihalogenoalkanes afford imidazo[l,2-a]pyridines via C,N-dialkylation.