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Alkylation of 2‘-Deoxynucleosides and DNA by the Premarin Metabolite 4-Hydroxyequilenin Semiquinone Radical

✍ Scribed by Shen, Li; Qiu, Shengxiang; Chen, Yumei; Zhang, Fagen; van Breemen, Richard B.; Nikolic, Dejan; Bolton, Judy L.


Book ID
127152945
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
189 KB
Volume
11
Category
Article
ISSN
0893-228X

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Formation of semiquinone radical in the
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Embelin, 2,5-dihydroxy-3-undecyl-1,4-benzoquinone, has two intra-molecular hydrogen bonds between the quinone and hydroquinone groups present on the same ring. Therefore, it is expected to produce semiquinone radical in the oxidation as well reduction reactions. To investigate this aspect, kinetics