2184. A new dimension in pyrrolizidine a
โฆ LIBER โฆ
Alkylation as the Mechanism by which the Hepatotoxic Pyrrolizidine Alkaloids Act on Cell Nuclei
โ Scribed by CULVENOR, C. C. J.; DANN, A. T.; DICK, A. T.
- Book ID
- 109622694
- Publisher
- Nature Publishing Group
- Year
- 1962
- Tongue
- English
- Weight
- 371 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/195570a0
No coin nor oath required. For personal study only.
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The tumor-initiating activities of the methanol extracts of polyetherurethanes (PEUs) were first detected in the presence of 12-O-tetradecanyl-phorbol-l3-acetate (TPA) using Balb 3T3 transformation assay. A model hard segment of PEUs, 4,4'-di(ethoxycarboamide) diphenylmethane (MDU), showed initiatin