Alkyl Carbonates: Efficient Three Component Coupling of Aliphatic Alcohols, CO 2 , and Alkyl Halides in the Presence of Cs 2 CO 3
โ Scribed by Kim, Seok-In; Chu, Feixia; Dueno, Eric E.; Jung, Kyung Woon
- Book ID
- 119952315
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 37 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
The presence of cesium carbonate and tetrabutylammonium iodide (TBAI) facilitated efficient O-alkylation of alcohols with alkyl halides, giving rise to the exclusive formation of mixed alkyl carbonates, The cesium effect was also examined comparatively with other alkali carbonates.
Mild and selective N-alkylation of carbamates was carried out in the presence of cesium carbonate, tetrabutylammonium iodide (TBAI), and a halide. This protocol was highly selective and efficient, offering aliphatic and aromatic N-alkyl carbamates exclusively in high yields.