Alkaloids of tylophora III: New alkaloids of Tylophora indica (burm) merrill and tylophora dalzellii hook. f

✍ Scribed by Koppaka V. Rao; Richard A. Wilson; Bernice Cummings

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 235 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600601133

✦ Synopsis

jection of the phlogistic agent. This was done to offset any possible error caused by the difference in the size of the animals used. The standard error of the mean (SEM) was calculated according to the formula given by Burn et al. (10):

where s j = SEM, = mean value, y = any single value, N = total number of animals used in the assay, and S = sum.

The method and techniques developed for the anti-inflammatory screening carried out in this investigation proved to be quite satisfactory. The method was simple and quick, and the apparatus was sufficiently sensitive for the determination of therapeutic levels of antiedema activity. Results with the hydrocortisone acetate and indomethacin, the control compounds, compared favorably with the results of others using antiedema assay procedures (2). Carrageenin seemed to possess a distinct advantage as a phlogistic agent because it produced an edema effectively controlled by the single, oral, nontoxic doses of the known anti-inflammatory agents used in the studies.