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Alkaloids in mammalian tissues. 4. Synthesis of (+)- and (-)-salsoline and isosalsoline

✍ Scribed by Teitel, Sidney; O'Brien, Jay; Pool, William; Brossi, Arnold


Book ID
125505666
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
593 KB
Volume
17
Category
Article
ISSN
0022-2623

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Synthesis of the optical isomers of (+)-methyl 6,7-dimethyl-3',4'-dideoxynorlaudanosoline-l-carboxylate ((k)-Z) was accomplished by reaction of (+)-2 with (+)-(R)-1-phenylethyl isocyanate, separation of the urea diastereoisomers (-)-4A and (+)-48, and alcoholysis of the ureas in refluxing BuOH. Opti