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Alkaline-treated poly(ϵ-caprolactone) films: Degradation in the presence or absence of fibroblasts

✍ Scribed by Juan Peña; Teresa Corrales; Isabel Izquierdo-Barba; M. Concepción Serrano; M. Teresa Portolés; Raffaella Pagani; María Vallet-Regí

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
660 KB
Volume
76A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

In the first stage, we observed the study of the degradation behavior of alkaline‐treated poly(ϵ‐caprolactone) (PCL) in two biologically‐related media: phosphate buffered saline (PBS) and Dulbecco's modified Eagle's medium (DMEM) for 18 months, finding a much accelerated degradation in the last one. As expected, the degradation in the presence of cells is much pronounced even considering that the study is limited to 6 months. The characterization of the degraded substrates by chemiluminescence (CL) allows to explain the modifications of the substrate and their relations with transitory oxidative stress phenomena described in the fibroblasts seeded onto the PCL membranes. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

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## Abstract This study investigated the __in vitro__ degradation behavior of poly(ϵ‐caprolactone/polyethylene glycol/L‐lactide) (PCEL) in comparison with that of three other biodegradable polymers. Polymer membranes were incubated in pancreatin solution, Ringer's solution, and distilled water at 37