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Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions

✍ Scribed by Ganna M. Shevchenko; Sergey A. Kulichenko

Book ID
111491152
Publisher
Versita
Year
2008
Tongue
English
Weight
224 KB
Volume
62
Category
Article
ISSN
0366-6352

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✦ Synopsis

Abstract

Protolytic properties of (+)-(S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (naproxen), 2-(3-benzoylphenyl)propionic acid (ketoprofen), 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid (furosemide), and N-(2,3-dimethylphenyl)anthranilic acid (mefenamic acid) in β€œoil-in-water” emulsions stabilized by surfactants were studied. The procedures for alkalimetric determination of naproxen, ketoprofen, furosemide, and mefenamic acid in emulsion media with indication of the equivalence point pH-metrically and with the use of indicators were proposed.

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