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ALK5 inhibition blocks TGFβ-induced CCN1 expression in human foreskin fibroblasts

✍ Scribed by Thompson, Katherine; Murphy-Marshman, Hannah; Leask, Andrew


Book ID
121542803
Publisher
Springer Netherlands
Year
2014
Tongue
English
Weight
268 KB
Volume
8
Category
Article
ISSN
1873-9601

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## Abstract Connective tissue growth factor (CTGF/CCN2) is a matricellular protein induced by transforming growth factor (TGF)‐β and intimately involved with tissue repair and overexpressed in various fibrotic conditions. We previously showed that keratinocytes in vitro downregulate TGF‐β‐induced e