ALK fusion genes in children with atypical myeloproliferative leukemia
✍ Scribed by Röttgers, S; Gombert, M; Teigler-Schlegel, A; Busch, K; Gamerdinger, U; Slany, R; Harbott, J; Borkhardt, A
- Book ID
- 109887222
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 432 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Chromosomal aberrations of 5q31‐33 associated with rearrangements of the platelet‐derived growth factor receptor beta (PDGFRB) gene are rare but recurrent in patients with eosinophilia‐associated atypical myeloproliferative neoplasms (Eos‐MPNs). We used a DNA‐based “long‐distance invers
The translocation t( IS; 17) associated with acute promyelocytic leukemia (APL) results in fusion of the retinoic acid receptor alpha (RARA) gene on chromosome I7 with the putative transcription factor gene. PML, on chromosome IS. We report three cases of APL with complex cytogenetic translocations