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ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor

✍ Scribed by Maria Debiec-Rychter; Peter Marynen; Anne Hagemeijer; Patrick Pauwels

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 238 KB
Volume: 38
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.10267

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✦ Synopsis

Abstract

In this report, we describe an inflammatory myofibroblastic tumor (IMT) of the urinary bladder in a 46‐year‐old man. Tumor cells presented striking cytoplasmatic ALK immunopositivity. Cytogenetic and FISH analysis, by use of a multicolor chromosome 2 banding probe, revealed a 46,XY,der(2)(2pter→2p23:2q35→2q37:2p11→2q35:2p23→2p11:2q37→2qter) karyotype. Subsequent FISH and RT‐PCR analysis confirmed the ALK‐ATIC chimeric fusion in tumor cells. This is the first evidence of a variant rearrangement involving the ATIC gene in IMT and the first cytogenetic description of an IMT originating from the urinary bladder. © 2003 Wiley‐Liss, Inc.

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