Alignment of Long DNA Molecules on Templates Generated via Dip-Pen Nanolithography

✍ Scribed by D. Nyamjav; A. Ivanisevic

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 304 KB
• Volume: 15
• Category: Article
• ISSN: 0935-9648
• DOI: 10.1002/adma.200305342

✦ Synopsis

A methodology to place and stretch long DNA molecules by coupling dip‐pen Nanolithography with molecular combing is presented. Templates were fabricated on SiO__~x~__ surfaces using a positively charged polymer, poly(allylamine hydrochloride). Upon molecular combing, DNA molecules elongate on the surface (for example, see Figure) and are localized by the presence of the charged lithographically defined structures.