We investigate a problem which arises in computational biology: Given a constant-size alphabet A with a weight function : A → N, ÿnd an e cient data structure and query algorithm solving the following problem: For a string over A and a weight M ∈ N, decide whether contains a substring with weight M , where the weight of a string is the sum of the weights of its letters (ONE-STRING MASS FINDING PROBLEM). If the answer is yes, then we may in addition require a witness, i.e., indices i 6 j such that the substring beginning at position i and ending at position j has weight M . We allow preprocessing of the string and measure e ciency in two parameters: storage space required for the preprocessed data and running time of the query algorithm for given M . We are interested in data structures and algorithms requiring subquadratic storage space and sublinear query time, where we measure the input size as the length n of the input string . Among others, we present two non-trivial e cient algorithms: LOOKUP solves the problem with O(n) storage space and O(n=log n) time; INTERVAL solves the problem for binary alphabets with O(n) storage space in O(log n) query time. We introduce other variants of the problem and sketch how our algorithms may be extended for these variants. Finally, we discuss combinatorial properties of weighted strings.