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Alginate/calcium phosphate scaffolds with oriented, tube-like pores

✍ Scribed by F. Despang; A. Börner; R. Dittrich; G. Tomandl; W. Pompe; M. Gelinsky

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 373 KB
Volume: 36
Category: Article
ISSN: 0933-5137
DOI: 10.1002/mawe.200500961

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✦ Synopsis

Porous and mineralised scaffolds are required for various applications in hard tissue engineering. Scaffolds with oriented tube-like pores facilitate homogenous cell seeding, a sufficient nutrient supply during cell culture (even in big constructs) and a fast vascularisation after implantation. The phenomenon of ionotropic gelation has been known since more than 30 years which describes that alginate forms gels with capillary-like pores when covered with solutions of di-or trivalent cations [1]. This technique has been used here to develop scaffolds with tube-like and regular pores from alginate/calcium phosphate composites and to stabilise them by mineralisation with hydroxyapatite from solution.

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## Abstract In this study, the alginate/calcium phosphate cement (CPC) scaffolds with oriented pore structure were fabricated by unidirectional freeze casting and poly (lactic‐__co__‐glycolic acid) (PLGA) was used to infiltrate into the macropores to strengthen the scaffolds. By modifying the liqui