A novel probe was developed to measure drug association with the F1\*S variant of the human serum protein alpha 1-acid glycoprotein (AGP). The molecule 2hydroxy-3,5-diiodo-N-[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenching its native ยฏuorescence. This quenching was ยฎtted to a two-site
โฆ LIBER โฆ
Algebraic Numbers Close to 1 and Variants of Mahler's Measure
โ Scribed by Francesco Amoroso
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 566 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-314X
No coin nor oath required. For personal study only.
โฆ Synopsis
Given a rational function R and a real number p 1, we define h p (R) as the L p norm of max[log |R|, 0] on the unit circle. In this paper we study the behaviour of h p (R) providing various bounds for it. Our results lead to an explicit construction of algebraic numbers close to 1 having small Mahler's measure and small degree, which shows that a lower bound for the distance |:&1| recently given by M Mignotte and M. Waldschmidt is also sharp. From our bounds also follows a statement on polynomials equivalent to the Riemann hypothesis.
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