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Alendronate Inhibits PTH (1–34)-induced Bone Morphogenetic Protein Expression in MC3T3-E1 Preosteoblastic Cells

✍ Scribed by Paul S. Issack; Margaret H. Lauerman; David L. Helfet; Stephen B. Doty; Joseph M. Lane


Book ID
107344166
Publisher
Springer
Year
2007
Tongue
English
Weight
247 KB
Volume
3
Category
Article
ISSN
1556-3316

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## Abstract Thrombospondin 1 (TSP1) is a multifunctional extracellular glycoprotein present mainly in the fetal and adult skeleton. Although an inhibitory effect of TSP1 against pathological mineralization in cultured vascular pericytes has been shown, its involvement in physiological mineralizatio